Glossary

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What is Tumor heterogeneity?
Tumor heterogeneity refers to the diversity observed within a tumor, encompassing differences in genetic, epigenetic, phenotypic, and functional characteristics among cancer cells within the same tumor mass. This heterogeneity can occur both spatially (across different regions within the tumor) and temporally (evolution of the tumor over time).

What is Tumor microenvironment?
The tumor microenvironment (TME) comprises various non-cancerous cells, such as immune cells, fibroblasts, blood vessels, and extracellular matrix components, present alongside cancer cells within the tumor. These components interact dynamically with cancer cells and each other, influencing tumor growth, invasion, metastasis, and responses to therapy. The interactions between tumor cells and the microenvironment play a crucial role in shaping tumor heterogeneity.

What is Spatial Biology?
Spatial biology is the analysis of cells within their native tissue environments. This can be a single RNA or protein visualized on the tissue or mapping of the subcellular coordinates of every RNA transcript and protein within the individual cells that make up the tissue.

What is Spatial Multiplex Multiomics?
Spatial multiplex multiomics integrates multiple omics datasets with spatial information, enabling researchers to investigate the spatial organization and interactions of molecular components (DNA, RNA, protein, or miRNA) in a tissue section.

What is Multiplexing?
Multiplexing is a powerful technique that allows researchers to simultaneously visualize multiple targets in a single sample. This is particularly valuable for studying complex biological systems and can help researchers better understand how different molecules and pathways interact with each other

 

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