TNF-alpha

TNF-alpha specifically affects the blood vessels associated with tumors (TAV) by causing increased passage ...of substances through the vessel walls and damaging the inner lining of the blood vessels. TNF can serve as a natural tumor promoter, connecting inflammation and the development of cancer. Indeed, recent reports indicate that TNF plays a role in every stage of cancer development, including cellular transformation, survival, growth, invasion, formation of new blood vessels, and spread to other parts of the body. TNF-alpha specifically affects the blood vessels associated with tumors (TAV) by causing increased passage of substances through the vessel walls and damaging the inner lining of the blood vessels. TNF-α has been linked to several human cancers, including breast, gastric, pancreatic, ovarian. It has also been detected in leukemias and lymphomas.