IDO1

IDO1 plays a crucial role in connecting inflammatory cytokines, showcasing its capability to generate ...an
inflammatory setting that supports the growth of tumors. IDO1 plays a key role in promoting tumor neovascularization by modulating the expression of interferon-γ (IFN-γ) and interleukin-6 (IL-6). IDO1 plays a role in developing resistance to immune checkpoint inhibitors, and combining an IDO1 inhibitor with checkpoint inhibitors is a different approach to cancer immunotherapy. IDO1 exhibits expression in acute myeloid leukemia, colorectal cancer, non-smallcell lung cancer, prostate cancer, and ovarian carcinoma.