ALK

Anaplastic lymphoma kinase (ALK) gene activation is involved in the carcinogenesis process of several ...human cancers such as anaplastic large cell lymphoma, lung cancer, inflammatory myofibroblastic tumors, and neuroblastoma, as a consequence of fusion with other
oncogenes (NPM, EML4, TIM, etc) or gene amplification, mutation or protein overexpression. ALK encodes a transmembrane receptor tyrosine kinase. This gene exerts characteristic oncogenic activities through fusion to several gene partners or mutations in hematopoietic and non-hematopoietic solid tumors. Activation of the ALK gene plays a role in the development of various human cancers including anaplastic large-cell lymphoma, lung cancer, inflammatory myofibroblastic tumors, and neuroblastoma.