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View productsAuthor: Dr. Krishan Kalra
Fremont, USA – Nov 01, 2022 – We at OmicsVeu1 are pleased to introduce a broad line of spatial multi-omics products that are compatible with our fully automated NanoVIP® platform.
The current research trends rely on emerging technologies like spatial multi-omics, where we can simultaneously assess genomic, transcriptomic, and proteomic changes at a sub-cellular resolution in the same tissue section. These multi-dimensional approaches are instrumental in analyzing the tumor microenvironments, which comprise a heterogeneous population of cells, and biomarkers that actively track and depict cancer progression. Characterizing the cellular and molecular architecture of the tumor microenvironments render valuable insight which enables the discovery of new cancer-associated, and immunological biomarkers which help accelerate the discovery and development of new diagnostics and therapeutic regimens, says Dr. Krishan Kalra, CEO of OmicsVeu.
OmicsVeu offers a set of tools with the following fully automated spatial multi-omics technologies and protocols:
These five multi-omics tools with high multiplexing capabilities, encompass a fully automated All-in-One NanoVIP®2 instrument, ready to use all assay reagents with optimized protocols to generate high-throughput, high-quality, reproducible & reliable data sets. Our fully automated system is designed to automate any manual slide-based protocol including but not limited to, Genotyping and Phenotyping, In situ sequencing, eFISH, miRFISH, low, medium, high, and hyper Immuno-plex.
The system offers TEN independently programmable workstations which makes NanoVIP® an ideal system for protocol optimization. It is equipped with eXACT™ temperature modules (up to 105oC) and liquid-level sensors for accurate liquid dispensing to ensure robust and reproducible results. The NanoVIP® software is intuitive and easy-to-use to create user-defined protocols and store them for future use with unparalleled capabilities. With high-quality engineered hardware, unique features, and one of the smallest footprints in the market, the system remains an ideal choice for spatial multi-omics.
About OmicsVeu
We provide an unconditional product performance guarantee & premier customer support. NanoVIP® is easy to set-up plug and play system, a game changer for spatial multi-omics. We offer ready-to-use probes and multiplex antibodies along with visualization kits and all required consumables with fully optimized protocols to accelerate the pace of multi-omics research. Further NanoVIP® is an open system designed to automate any manual slide-based protocols with OmicsVeu or user-supplied reagents.
For further information contact:
48810 Kato Road,
Suite 100E & 200E, Fremont, CA 94538 USA
Tel: +1 510-824-1400
Email: customerservice@localhost
Watch Video: https://youtu.be/PhrPTmfJLGQ
Brochure: https://omicsveu.com/wp-content/uploads/Brochures/NanoVIP_Brochure_937-4124.0.pdf
1) OmicsVeu is a wholly owned subsidiary of BioGenex
2) NanoVIP® a fully automated staining system for FFPE, Frozen Tissues sections and Cyto-preps, provides slides ready for Imaging or for Imaging Mass Cytometer & CellProfiler.
Doc. no. 937-4126.0
Conclusion
In situ sequencing is a targeted image-based technology that can detect gene expression and provide location information within a cell sample or a tissue section. This tool is valuable for understanding the pathology and molecular mechanisms of diseases. So far, it has been applied in various areas, such as cancer diagnosis, gene expression profiling, and mutation detection. Providing gene expression images and spatial context using ISS results in an atlas-like map which has been used to develop The Human Developmental Cell Atlas. The project is a Swedish initiative developed by the Science for Life Laboratory, which aims to create a detailed molecular atlas of human cell types and show their spatial distributions in three dimensions.
References:
- Chen, W.-T. et al. (2020) “Spatial transcriptomics and in situ sequencing to study alzheimer’s disease,” Cell, 182(4). Available at: https://doi.org/10.1016/j.cell.2020.06.038.
- Hilscher, M.M. et al. (2021) “Correction to: In situ sequencing: A high-throughput, multi-targeted gene expression profiling technique for cell typing in tissue sections,” Methods in Molecular Biology [Preprint]. Available at: https://doi.org/10.1007/978-1-0716-0623-0_25.
- In situ sequencing (2022) SciLifeLab. Available at: https://www.scilifelab.se/units/in-situ-sequencing/ (Accessed: December 4, 2022).
- Ke, R., Mignardi, M., Pacureanu, A. et al. In situ sequencing for RNA analysis in preserved tissue and cells. Nat Methods 10, 857–860 (2013). https://doi.org/10.1038/nmeth.2563
- The Human Developmental Cell Atlas (no date) HDCA Sweden. Available at: https://hdca-sweden.scilifelab.se/ (Accessed: December 4, 2022).